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The Mineral Matrix: Why Your Supplements Aren’t Working (And What Actually Does)

Kristie Leong M.D.
7 min readJan 29, 2025

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Here’s a truth you might not be ready for: that expensive supplement stack gathering dust on your counter? It might be nothing more than expensive urine in the making.

I know, I know. You’ve spent your hard-earned money on colorful supplement pills, the ones that promise everything from superhuman energy to a sharper mind, and brain-bending focus.

And one thing is clear. The supplement industry, worth a staggering $151.9 billion globally, knows how to play you. They’ve mastered the art of selling hope in a bottle. And they sway you subconsciously with clever advertising and marketing speak.

But here’s what they don’t want you to know — and what cutting-edge research reveals about why most supplements don’t deliver on their promises.

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The Bioavailability Betrayal

Here’s the thing about minerals and vitamins: they’re complicated little dancers in your body’s biochemical nightclub. They don’t just waltz straight into your bloodstream looking for cells to help.

Instead, they need the right partners, the perfect pH, and specific molecular bouncers to let them in. And keep this in mind:

It’s not how much you take of a mineral that matters, it’s how much your body absorbs and can use, referred to as bioavailability.

Take iron, for example. That iron supplement you’re popping into your mouth and washing down with filtered water? Your body might only absorb about 2–20% of it. The rest? It’s taking the express route to your toilet.

Your body absorbs iron that you get from plant-based sources, known as non-heme iron, less well than it does iron from animal sources. But why?

Photo by Louis Hansel on Unsplash

Plant-based iron sources contain natural compounds such as phytic acid and oxalates that bind to minerals, like iron, and make them harder for your…

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Kristie Leong M.D.
Kristie Leong M.D.

Written by Kristie Leong M.D.

Ready to change your health trajectory? As a family physician, I'll help you build a path to lasting health—one meal at a time." https://www.histaminedoctor.com

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